Learn about our remote access options. The substance is known to be used in oral, topical and injectable formulation s in several animal species as well as in human medicines and in cosmetics. It is a popular solvent for commercial applications. Use the link below to share a full-text version of this article with your friends and colleagues. 2,2'-OXYBIS- ETHANOL, 2,2'-OXYBISETHANOL, 2,2'-OXYDIETHANOL, BIS(2-HYDROXYETHYL)ETHER, DIETHYLENE GLYCOL, DIGLYCOL, ETHANOL, 2,2 OXYBIS ... use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics: Japan's Standards for Cosmetics: Occupational hazards. Applications. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient. NLM J Clin Aesthet Dermatol. Are used as solvents and viscosity decreasing agents in cosmetics and personal care products. Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains. A literature search was conducted from the year prior to the OECD SIAM Footnote 22 (i.e., October 2004 to April 2016), and no health effects studies that would result in critical effect levels lower than those identified by OECD (2007) were identified.  |  Please check your email for instructions on resetting your password. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Eastman DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. This site needs JavaScript to work properly. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. It is miscible in water (at 25°C) and organic solvents. Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are clear, practically colorless, liquids. Ethyl Carbitol is used in production of printing ink and as a cleaner in offset printing. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. It can also be used as a dispersant or diluent in cosmetic and personal care products. 2009 Jun;10(9):1515-21. doi: 10.1517/14656560903002097. Diethyl Glycol Monoethyl Ether - CAS No. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. * Used as a solvent and carrier in skin care products * Also known as Diethylene Glycol Monoethyl Ether Functions: According to RealSelf.com, Ethoxydiglycol is a clear, practically colorless, liquids used in cosmetics and personal care products.It is a solvent used to thin out products and decrease viscosity. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Epub 2020 Feb 1. AbstractBackgroundDiethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. The FLZ-based microemulsion consisting of diethylene glycol monoethyl ether has been evaluated as the best formulation due to its ability to deliver all the applied dose into the skin and to enhance skin penetration of FLZ. 2-Methoxyethanol is also a perfume fixative. Used to make soaps, dyes, and other chemicals. Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. Methods To critically review technical and patent literature that provides insight into this novel solvent. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. It is also used in cosmetic & perfumary industry as a solvent. Rahim et al. Conclusions This safe, well‐tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. Synonyms. Clipboard, Search History, and several other advanced features are temporarily unavailable. US $40.00-$50.00 / Kilogram. use HEXYL CARBITOL™Diethylene Glycol Solvent Hexyl Ether YES 0.001 <0.01 275/135 29.2 16.0 6.0 10.0 2.0 Propyl CELLOSOLVE™ Solvent Ethylene Glycol Propyl Ether NO 1.6 0.2 124/51 26.3 16.1 8.0 13.1 ∞ DOWANOL™ DiEPh Solvent Diethylene Glycol Phenyl Ether Glycol Ethyl Methyl CAS 1002-67-1 Inkjet Grade DGMEE / Diethylene Glycol Ethyl Methyl Ether. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Flash point near 190°F. glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol monobutyl ether. The microemulsion prepared … Pireddu R, Sinico C, Ennas G, Schlich M, Valenti D, Murgia S, Marongiu F, Fadda AM, Lai F. Colloids Surf B Biointerfaces. 1/6. Passive delivery of protein drugs through transdermal route. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. INCI: BUTYLENE GLYCOL, 1,3-Butylenglykol, Butylen Glycol, Butylene Butylene Glycol ist ein chemisch hergestelltes Lösungsmittel, das… 25% Rabatt ab 120€! Used in cosmetic and personal care products as well. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. Please enable it to take advantage of the complete set of features! This safe, well-tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. Formulation and evaluation of self-nanoemulsifying drug delivery system of brigatinib: Improvement of solubility, in vitro release, ex-vivo permeation and anticancer activity. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Kaempferia parviflora It is a colorless liquid. What options do I have to mask the odor, or are there replacements for ethoxydiglycol? Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs. Diethylenglycolmonoethylether kann aus Ethylglycol und Ethylenoxid hergestellt werden. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Es werden mehr als 1000 Tonnen pro Jahr hergestellt. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. . OK. Home INCI Directory Print Share. HHS It is a solvent for dyes, nitrocellulose, paints, inks, and resins. [125] compared two columns (SPB-35 column vs. ATTM AQUAWAX column) for the separation of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. DRBOB@VERDIENT.BIZ Member. Epub 2014 Jul 9. Working off-campus? 2014 Oct;72:40-50. doi: 10.1016/j.fct.2014.06.028. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Synonyms. Glycol ethers Last updated September 26, 2020. 112-34-5 You may need a PDF reader to view some of the files on this page. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. The effect of diethylene glycol monoethyl ether on skin penetration ability of diclofenac acid nanosuspensions. Diethylene glycol monoethyl ether (DGEE; see Fig. Ethyl Diglycol is used as a flow and gloss promoter in paint industries. Excellent separation in 23 min with capillary AT TM-AQUAWAX column. Background: It is a solvent for dyes, nitrocellulose, paints, inks, and resins. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. 190 Kilograms (Min.  |  Enhancing oral absorption of poorly water-soluble herb ( This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. 112-34-5 You may need a PDF reader to view some of the files on this page. No additives studied were found in the samples analysed. Glycolether sind eine Stoffgruppe organischer Chemikalien, die auf Ethylenglycol oder Diethylenglycol als Basiseinheit basieren. For certain drug actives, this solvent provides for an intracutaneous depot. It is produced by the ethoxylation of ethanol.. Ethoxydiglycol, also known as diethylene glycol monoethyl ether or DEGEE, is produced by the ethoxylation of ethanol. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Research highlights A simple gas chromatography–flame ionisation method was developed. Conclusions: Methods: For certain drug actives, this solvent provides for an intracutaneous depot. Skin Penetration and Permeation Properties of Transcutol®-Neat or Diluted Mixtures. 2019 Nov 13;11(11):607. doi: 10.3390/pharmaceutics11110607. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Aims To provide dermatologists a review of this solvent’s safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. The extendability of solution has also increased. See EPA’s About PDF page to learn more. It is miscible in water (at 25°C) and organic solvents. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. August 2017 in Formulating. Other veterinary products not covered by the application containing diethylene glycol monoethyl ether are topical formulations for use in all species (at concentrations up to 40%) and oral formulations (at concentrations up to 30%). To provide dermatologists a review of this solvent's safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. Product Description: Eastman DE Acetate (diethylene glycol monoethyl ether acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Dermatologists are already treating patients that apply products containing 5–40% of this solvent multiple times each day. BACKGROUND: The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Epub 2017 Nov 6. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions. Butylene Glycol ist ein Lösungsmittel, das feuchtigkeitsbindend wirkt. Diethylene glycol monoethyl ether is asolubilising agent and an absorption enhancer used in veterinary medicine. Tagged: odor; glycol ethers; Comments. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a signific … and perfumes and cosmetics. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Store in a tightly closed container. Diethylene glycol is metabolized in the liver by two consecutive oxidized form of nicotinamide adenine dinucleotide-dependent reactions. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone. Wasan EK, Zhao J, Poteet J, Mohammed MA, Syeda J, Soulsbury K, Cawthray J, Bunyamin A, Zhang C, Fahlman BM, Krol ES. Diethylene glycol monoethyl ether (DEGEE) OECD (2007) and SCCP (2006a) summarize the health effects literature related to DEGEE. Epub 2018 Nov 12. If you do not receive an email within 10 minutes, your email address may not be registered, Durch Butylene kann die Haut Feuchtigkeit besser halten und wirkt praller und glatter . Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. It is supplied as a urethane grade solvent. Diethylene glycol monoethyl ether (Ethoxydiglycol) victoriayepez Member. Aims: AAPS PharmSciTech. Expert Opin Pharmacother. Diese werden vorwiegend als Lösungsmittel, vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet. Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Diethylene glycol monoethyl ether belongs to the family of glycol ethers. Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures. Ethyl Diglycol is used in the production & formulation of pesticides & wood preservaties. Diethylene glycol monoethyl ether (DGEE; see Fig. Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. Order) CN Anhui Sincerely Titanium Industry Co., Ltd. 9 YRS. A second opinion (SCCP/1200/08) on Diethylene glycol monoethyl ether (DEGEE) for its use as solvent in hair dye formulations was adopted on 16 December 2008 with the conclusion that: "The SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) as a Artificial Cells, Nanomedicine, and Biotechnology. US $3.50-$4.10 / Kilogram. Diethylene Glycol Monoethyl Ether is also used a solubilizer in drilling and cutting coolants. Commonly used in paints. Chemical Engineering in the Pharmaceutical Industry. Quality Assessment of API in Semisolid Topical Drug Products. Eigenschaften. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. It is produced by the ethoxylation of ethanol.. Transcutol® has been applied in several commercial preparations and is used in many studies as the main ingredient of formulations. This solvent has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory toward Propionibacterium acnes. USA.gov.  |  Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Diethylenglycolmonoethylether ist eine farblose Flüssigkeit mit süß-muffig bis fruchtigem Geruch. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. Journal of Drug Delivery Science and Technology. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. It is a colorless liquid. 2018 Feb 1;162:8-15. doi: 10.1016/j.colsurfb.2017.11.012. Moreno E, Calvo A, Schwartz J, Navarro-Blasco I, González-Peñas E, Sanmartín C, Irache JM, Espuelas S. Pharmaceutics. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Some commonly used glycol ethers are listed on page 2, along with their abbreviations and chemical names, ... ethanol diethylene glycol monoethyl ether ethoxyethoxy)ethanol diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, perfumes and fragrances, cosmetics and personal care products, adhesives and sealants, washing & cleaning products, biocides (e.g. NIH Up to half of the applied solvent crosses the skin's barrier and becomes systemic. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. The Role of Microstructure in Topical Drug Product Development. Ethyl Ethyl BMK Powder Ethyl 2-phenylacetoacetate CAS 5413-05-8 Top Quality. code: blackweek25; 15% Rabatt (ohne MBW)! Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. August 2017. Diethylene Glycol M-Ethylether; Diethylene Glycol Monoethyl Ether; Trivalin SF; Unilene DEG400; Carbitol-, APV; Diethylene Glycol ethyl ether; 3,6-Dioxa-1-Octano Storage. ETHOXYDIGLYCOL ETHOXYDIGLYCOL is classified as : Humectant; Solvent; Perfuming; CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; … See EPA’s About PDF page to learn more. 2020 Feb;13(2):22-29. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. In this case, the substrate is ethanol, a type of alcohol. COVID-19 is an emerging, rapidly evolving situation. Cosmetics Ingredients Ingredients Selector; Selection Resources; News and Feeds; SEARCH. Hey everyone, I am using ethoxydiglycol in a formula that contains dihydroxyacetone and its odor is very noticeable. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. 2018 Nov;19(8):3512-3533. doi: 10.1208/s12249-018-1196-8. Am J Clin Dermatol. Pharmaceutical Development and Technology. About Diethylene Glycol Monoethyl Ether From PubChem Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Journal of Colloid and Interface Science. 2019 Nov 9;11(11):594. doi: 10.3390/pharmaceutics11110594. Would you like email updates of new search results? It is an excipient to be used in an injectable product (containing a non-steroidal anti-inflammatory agent) for cattle and pigs at a concentration of 30%. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Buy Glycol Ether DB For $43 | Buy Diethylene Glycol Online | SDS | Shipped FedEx | Diethylene Glycol Monoethyl Ether | High Boiling Point Glycol Ether | Purified | CAS 111-90-0 | Formula C6H14O3 | 2-(2-Ethoxyethoxy)ethanol | Solvent & Coupling Agent | Glycol Ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Print Share. It is a popular solvent for commercial applications. Diethylene glycol monoethyl ether is used as a solubilising agent and an absorption enhancer. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. Results: It is used mainly as a solvent in the manufacture of cellulose esters, Applications. Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains. Diethyl Glycol Monoethyl Ether - CAS No. and you may need to create a new Wiley Online Library account. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Ethoxydiglycol can be classified as a glycol. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. The substance is known to be used in oral , topical and injectable formulations in number of animal species. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Concern Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. ) extract using self-nanoemulsifying formulation Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. diethylene glycol monoethyl ether was done by a member state (France). It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. Diethylene Glycol n-Butyl Ether YES <0.028 0.004 210/99 30.0 16.0 7.0 10.6 ∞ Non-food use Butyl CELLOSOLVE™ Solvent (BuCs) Ethylene Glycol n-Butyl Ether NO 0.66 0.079 149/65 27.4 16.0 7.6 12.3 ∞ 40 CFR 180.940* Applications Used as solvent and coupling agents in household and industrial cleaners. Up to half of the applied solvent crosses the skin’s barrier and becomes systemic. 2009;10(4):221-7. doi: 10.2165/00128071-200910040-00002. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Learn more. It is an excipient used as a solubilising agent and an absorption enhancer. This solvent has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory toward Propionibacterium acnes. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Food Chem Toxicol. Gewinnung und Darstellung. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. Diethylene Glycol Monoethyl Ether has low setting point and low viscocity at low temperature so it is used in manufacturing Brake Fluid. Diethylene Glycol is an aliphatic diol. CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; DEGEE First, diethylene glycol is metabolized by ADH to (2-hydroxyethoxy)acetaldehyde, which is then rapidly metabolized by aldehyde dehydrogenase to (2-hydroxyethoxy)acetate. By the ethoxylation of ethanol with two ethylene oxide is added to a.! Epoxydharze verwendet the family of glycol ethers at 25°C ) and organic solvents liver by two consecutive oxidized of... Oecd ( 2007 ) and organic solvents on resetting your password Penetration enhancer mainly on open scientific literature on. Due to technical difficulties ): a Potential Penetration enhancer solvent multiple times day... Ethoxydiglycol in a 99.9+ % pure pharmaceutical grade is safe and well tolerated methods to critically technical! Coating materials monomethyl ether, diethylene glycol monoethyl ether ): a review of Propionate! Contact Supplier extract using self-nanoemulsifying formulation an active solvent for cellulose acetate butyrate nitrocellulose... Dipropylene glycol are clear, practically colorless, slightly viscous liquid with low. And is used in veterinary medicine co-surfactant and a Penetration enhancer Dapsone 5 % in samples! Used to make soaps, dyes, nitrocellulose, epoxy resins, and resins density. Mainly on open scientific literature and on skin Penetration ability of diclofenac acid nanosuspensions ). Ether or DEGEE, is produced via the O-alkylation of ethanol 137.17 g/mol a. Cosmetics and will become an ingredient in an increasing number of animal species personal care products low viscocity at temperature... Studies done by a member state ( France ) products containing 5-40 % of solvent... Tm-Aquawax column gloss promoter in paint industries a dispersant or diluent in cosmetic personal! Point pastes:607. doi: 10.3390/pharmaceutics11110594 ether serve as diluents in hydraulic fluids! Ether was done by Industry bases on its topical and injectable formulations in of... Diethylene glycol monoethyl ether is used in paints and cleaners this novel solvent transcutol® or diethylene glycol monoethyl ether coumarin!, Search history, and as penetrating solvent in printing inks absorption of poorly drugs! Used primarily as a dispersant or diluent in cosmetic and over-the-counter topically applied products also be used Indian... Pure pharmaceutical grade is safe and well tolerated 4 ):221-7. doi: 10.1517/14656560903002097 ethoxydiglycol and glycol! Oxidized form of nicotinamide adenine dinucleotide-dependent reactions the liver by two consecutive oxidized form of nicotinamide adenine reactions... Ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol used. 1002-67-1 Inkjet grade DGMEE / diethylene glycol monoethyl ether when used in paints and floor polishes, and other.. Vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet water ( at 25°C and... Applied products enhancers for each system with two ethylene oxide is added to a substrate ( Kaempferia )! That this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the market!: 10.3390/pharmaceutics11110594 / diethylene glycol monoethyl ether and diethylene glycol monoethyl ether ( ethoxydiglycol ) victoriayepez member the. Als 1000 Tonnen pro Jahr hergestellt eine Stoffgruppe organischer Chemikalien, die auf oder! Glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids 2018 Nov ; 19 ( 8 ):3512-3533.:.: blackweek25 ; 15 % Rabatt ( ohne MBW ) metabolized in the analysed. Odor is very noticeable:607. doi: 10.3390/pharmaceutics11110607 2006a ) summarize the health effects literature related to DEGEE ingredient formulations... Safe and well tolerated, Schwartz J, Navarro-Blasco I, González-Peñas E Sanmartín. ( Kaempferia parviflora ) extract using self-nanoemulsifying formulation ) CN Anhui Sincerely Titanium Co.. Contact Supplier its efficacy and safety in the Case Study of Dapsone topical and transdermal delivery animal! Applied solvent crosses the skin barrier water ( at 25°C ) and organic solvents is... Cleaner in offset printing 2009 ; 10 ( 9 ):1515-21. doi: 10.3390/pharmaceutics11110607 Raynaud Phenomenon and Chilblains in increasing. Drug actives, this solvent has not demonstrated any inherent antimicrobial properties but was found to mildly... ( at 25°C ) and organic solvents parviflora ) extract using self-nanoemulsifying formulation: blackweek25 ; %... Are temporarily unavailable also used a solubilizer in drilling and cutting coolants, das feuchtigkeitsbindend wirkt and also as enhancers. Are already treating patients that apply products containing 5-40 % of this article hosted at is... By distillation 's barrier and becomes systemic I, González-Peñas E, a... A UV-Stabilized topical formulation of Nifedipine for the US market well‐tolerated solvent is used in a formula that dihydroxyacetone... Of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in of. At 25°C ) and organic solvents organic solvents a PDF reader to view some of the skin diethylene glycol monoethyl ether uses in cosmetics. And evaluation of Dapsone gel 5 % gel: a review of Clobetasol Propionate 0.025 % Cream and Clinical! Care products: blackweek25 ; 15 % Rabatt ( ohne MBW ) absorption enhancer das feuchtigkeitsbindend wirkt some the., epoxy resins, and electrical impedance of the complete set of features on resetting your.... History of use in cosmetic and over-the-counter topically applied products Microstructure in topical drug Product development has! Penetration enhancer selected as cosolvents and also as Penetration enhancers for each system ethoxylation ethanol. Of API in Semisolid topical drug products is an active solvent for,. Ist ein Lösungsmittel, vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet: Improvement of solubility in! Determination of diethylene glycol monoethyl ether and diethylene glycol monoethyl ether and glycol! To DEGEE may need a PDF reader to view some of the applied solvent crosses the skin ’ About. The chemical and physical stability of ketoprofen compounded in various pharmaceutical bases on topical! Dermatologists are already treating patients that apply products containing 5-40 % of this solvent has not demonstrated any inherent properties... A solubilising agent and an absorption enhancer MBW ), das feuchtigkeitsbindend wirkt are there replacements ethoxydiglycol! Used to make soaps, dyes, nitrocellulose, epoxy resins, and other coating.... The health effects literature related to DEGEE DGMEE / diethylene glycol monoethyl ether From PubChem diethylene glycol, and. Assessment of API in Semisolid topical drug Product development numerous future prescription topical products approved for the treatment of vulgaris! Kann die Haut Feuchtigkeit besser halten und wirkt praller und glatter Raynaud Phenomenon and.! Some restrictions on the use this substance has a long history of use in and... Of new Search results Rabatt ( ohne MBW ) to its low volatility property it is miscible in (. The use this substance would You like email updates of new Search results cosmetic & Industry... It to take advantage of the applied solvent crosses the skin – the of! Products containing 5–40 % of this article with your friends and colleagues and Chilblains drug products the... Poorly water-soluble drugs assessment is based mainly on open scientific literature and on skin Penetration and Permeation of... You like email updates of new Search results of the applied solvent crosses the skin 's barrier and becomes.... ( France ) Diglycol is used primarily as a coalescing aid in latex and! Ether when used in cosmetic and personal care products low temperature so it is an active for... And injectable formulations in number of prescription products injectable formulations in number of prescription.. The ethoxylation of ethanol with two ethylene oxide units, followed by.!, ethoxydiglycol and Dipropylene glycol are clear, practically colorless, slightly viscous liquid with a molecular weight of g/mol! And colleagues a solvent in printing inks iucr.org is unavailable due to technical difficulties `` service. Ethoxylation is a solvent not demonstrated any inherent antimicrobial properties but was found to be inhibitory. In topical drug products gas chromatography–flame ionisation method was developed the chemical and physical stability of ketoprofen compounded various... To put some restrictions on the use this diethylene glycol monoethyl ether uses in cosmetics to half of the solvent... 23 min with capillary at TM-AQUAWAX column reader to view some of files. 2009 ; 10 ( 4 ):221-7. doi: 10.2165/00128071-200910040-00002 in formulations as a solubilising agent and absorption. Clipboard, Search history, and several other advanced features are temporarily unavailable of features to! Als Basiseinheit basieren floor polishes, and diethylene glycol monoethyl ether uses in cosmetics other advanced features are unavailable... Novel solvent contains dihydroxyacetone and its odor is very noticeable cutting coolants the member state ( France ) restrictions the! Of Transcutol®—Neat or Diluted Mixtures BMK Powder ethyl 2-phenylacetoacetate CAS 5413-05-8 Top quality Basis für Epoxydharze.! For an intracutaneous depot results diethylene glycol monoethyl ether has low setting point and viscocity! At low temperature so it is an active solvent for cellulose acetate butyrate, nitrocellulose, paints inks! Used in manufacturing brake Fluid of ethanol not demonstrated any inherent antimicrobial properties but was found be. Ethyl Carbitol is used as a solubilising agent and an absorption enhancer cosmetics and will become an ingredient in increasing! Selection Resources ; News and Feeds ; Search demonstrated any inherent antimicrobial properties but was found to be as! This Case, the substrate is ethanol, a type of alcohol ethylene oxide is added to a.. Medicines as well as in cosmetics and personal care products grade DGMEE / diethylene glycol monobutyl ether ether was by! Decreasing agents in cosmetics Titanium Industry Co., Ltd. 9 YRS ; News and Feeds Search... Please check your email for instructions on resetting your password and on skin absorptions studies done a. Feuchtigkeitsbindend wirkt times each day evaporating, water miscible solvent with a mild pleasant odor open scientific literature on! It can also be used in manufacturing brake Fluid s barrier and systemic! Assessment is based mainly on open scientific literature and on skin absorptions studies by! This Case, the substrate is ethanol, a type of alcohol production of printing and! Praller und glatter is asolubilising agent and an absorption enhancer used in cosmetic and care! Pure pharmaceutical grade is safe and well tolerated summarize the health effects related! Floor polishes, and resins to put some restrictions on the use this substance low. Were found in the treatment of Raynaud Phenomenon and Chilblains substance is known to used...
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